I installed the 10.7.4 update with two usb monitors DEll 23'inch P2310H and it caused alot of issues for my MBP. CPU was running at nearly 100% after waking up from the first sleep. The computer became completely unresponsive and felt to be overheating. The dispalys also would not response most times after waking up from sleep. I wiped by hard drive and reinstalled from a time machine backup from 10.7.3 and everything was back to normal.
mid 2010 mbp Crucial M4 SSD 8GB Ram. Two- 23inch Dell P2310H (1 is USB and the other mini display port) and One - 23inch Gateway (USB)